Symptoms Of Allergies

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Symptoms and leukotrienes

In a clinical study of children with allergic rhinitis11

As pollen count rose, leukotrienes and symptoms increased.

Study objective: To evaluate the production of leukotriene C4 in the upper respiratory tract of ragweed-sensitive children during naturally acquired exposure to atmospheric ragweed pollen during ragweed season.

Leukotriene concentrations and symptom severity were measured before, during, and after the pollen season.

Symptoms Of Allergic Rhinitis

Symptoms includeda:

  • Congestion
  • Rhinorrhea
  • Sneezing

aSymptom scores were compiled weekly from patients' daily diaries.

1. Pollen count
From the first measurement, pollen count increased.

Pollen Count Graph

2. Leukotriene concentrations
Increases in pollen count correlated with increases in leukotriene concentrations.

Leukotrienes Concentration Graph

3. Symptom scores
As leukotriene concentrations increased, symptom severity increased.

Graph of Allergy Symptoms Scores = Time period when graphed variables reached their peak (August 20–30).

Mean symptom scores of patients followed a pattern similar to that of leukotriene concentration.
—There was no direct correlation between individual patients' leukotriene C4 levels and their symptom scores.

Study Design: Sixteen children aged 5 to 12 years participated in this study. All 16 were ragweed sensitive; 6 were also mold sensitive. A control group of 12 healthy subjects with no history of allergy to ragweed was included. The objective of this study was to evaluate the production of leukotriene C4 in the upper respiratory tract of ragweed-sensitive children during naturally acquired exposure to atmospheric ragweed pollen during ragweed season in the community.11

From Volovitz et al. J Allergy Clin Immunol. 1988;82:414–418. Copyright 1988. The American Academy of Allergy, Asthma and Immunology. Adapted with permission from Elsevier Inc. All rights reserved.

Continue to Increased eosinophils

SINGULAIR is indicated for relief of symptoms of allergic rhinitis (seasonal allergic rhinitis in adults and children aged 2 years and older and perennial allergic rhinitis in adults and children aged 6 months and older).

SELECTED SAFETY INFORMATION

  • Neuropsychiatric events have been reported in patients taking SINGULAIR. These events included agitation, aggressive behavior or hostility, anxiousness, depression, dream abnormalities, hallucinations, insomnia, irritability, restlessness, somnambulism, suicidal thinking and behavior (including suicide), and tremor. The clinical details of some postmarketing reports appear consistent with a drug-induced effect. Patients should be advised to report any neuropsychiatric events.
  • In clinical trials in patients with allergic rhinitis, adverse events varied by age. The most commonly reported adverse events, occurring at a frequency of >1% and at an incidence greater than placebo, regardless of causality assessment, were sinusitis, upper respiratory infection, sinus headache, cough, epistaxis, headache, otitis media, pharyngitis, and increased ALT.
  • SINGULAIR is contraindicated in patients with hypersensitivity to any component of this product.

Before prescribing SINGULAIR, please read the Prescribing Information.

20951837(3)-02/10-SNG

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