Information On Asthma

The information on this site is intended for health care professionals in the United States and is not intended for the general public.

I AM A HEALTHCARE PROFESSIONAL I AM NOT A HEALTHCARE PROFESSIONAL
Prescribing Information Patient Information Selected Safety Information Return to singulair.com

References

  1. Malmstrom K, Rodriguez-Gomez G, Guerra J, et al; for Montelukast/Beclomethasone Study Group. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma: controlled trial. Ann Intern Med. 1999;130(6):487–495.
  2. Data available on request from Merck, Professional Services-DAP, WP1-27, PO Box 4, West Point, PA 19486-0004. Please specify information package RESP-1007093-0000.
  3. Reiss TF, Chervinsky P, Dockhorn RJ, et al; for Montelukast Clinical Research Study Group. Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Arch Intern Med. 1998;158(11):1213–1220.
  4. Busse WW, Casale TB, Dykewicz MS, et al. Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity. Ann Allergy Asthma Immunol. 2006;96(1):60–68.
  5. Data available on request from Merck, Professional Services-DAP, WP1-27, PO Box 4, West Point, PA 19486-0004. Please specify information package ASTH-1003955-0000.
  6. Knorr B, Matz J, Bernstein JA, et al; for Pediatric Montelukast Study Group. Montelukast for chronic asthma in 6- to 14-year-old children: a randomized, double-blind trial. JAMA. 1998;279(5):1181–1186.
  7. Williams B, Nooman G, Reiss TF, et al. Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and childrens 6 years and older. Clin Exp Allergy. 2001;31(6):845–854.
  8. Laitinen LA, Laitinen A, Haahtela T, et al. Leukotriene E and granulocytic infiltration into asthmatic airways. Lancet. 1993;341(8851):989–990.
  9. Lee E, Robertson T, Smith J, et al. Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals. Am J Respir Crit Care Med. 2000;161(6):1881–1886.
  10. Spada CS, Nieves AL, Krauss AH-P, et al. Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro. J Leukoc Biol. 1994;55(2):183–191.
  11. Fregonese L, Silvestri M, Sabatini F, et al. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a CysLT1 receptor-mediated mechanism. Clin Exp Allergy. 2002;32(5):745–750.
  12. Nagata M, Saito K, Tsuchiya K, et al. Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. J Allergy Clin Immunol. 2002;109(4):676–680.
  13. Rothenberg ME. Eosinophilia. N Engl J Med. 1998;338(22):1592–1600.
  14. Barnes PJ. Pharmacology of airway smooth muscle. Am J Respir Crit Care Med. 1998;158(5):S123–S132.
  15. American Academy of Allergy, Asthma & Immunology. Asthma triggers and management: tips to remember.
    aaaai.org/patients/publicedmat/tips/asthmatriggersandmgmt.stm. Accessed October 24, 2011.
RESP-1007091-0003 01/12

For general information and other services for physicians

Merck Services Merck OnCall